Noncoding RNAs and Cardiac Fibrosis

Myocardial fibrosis is a common pathological feature of various terminal cardiovascular diseases. Progressive the basis for development and progression many cardiac arrhythmias heart failure. There are no effective reversal drugs myocardial due to lack understanding molecular mechanisms. Noncoding RNAs, class RNAs that do not function in coding proteins, have been found be intimately involved life cycle cardiomyocyte differentiation, transcription apoptosis important regulators disease. An increasing number studies shown noncoding regulate proliferation transformation fibroblasts through related signaling pathways can used as potential biomarkers novel therapeutic targets fibrosis. This article reviews relationship between